IMMUNOHISTOCHEMISTRY BASED CHARACTERIZATION OF NON- SMALL CELL LUNG CARCINOMA IN A TERTIARY CARE CENTRE OF EASTERN INDIA.

NTRODUCTION- Lung malignancies are the leading cause of cancer-related mortality in industrialized countries. Lung malignancies are traditionally classied as Non-Small Cell Lung Carcinoma(NSCLC) and Small Cell Lung Carcinoma. The NSCLCs are the most common type and is further subclassied into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. This is aMATERIAL AND METHODS- cross-sectional study done between 2019 and 2021 at the tertiary cancer centre at Jharkhand. A total of 100 diagnosed cases of Non-small cell lung cancer by histopathological examination of lung biopsy are included in this study. Followed by immunohistochemistry with p63, TTF-1, Napsin A, and CK 5/6. Out of 100 cases, 60 cases were of adenocarcinoma and 40 cases of squamous cell carcinoma. Among those 60 cases ofRESULTS- adenocarcinoma, NapsinAwas positive in 85% cases and TTF-1 was positive in 93% cases, CK5/6 and p63 positivity was seen in 7 % and 8% cases respectively. Out of 40 cases of squamous cell carcinoma, 92% cases were immunoreactive for CK5/6 while p63 was positive in 85% cases, 25% cases were also positive for TTF-1. In our study, Napsin A was more specic than TTF-1 regarding the diagnosis of lungDISCUSSION- adenocarcinoma, and CK5/6, having more specicity than p63, showed signicant immunoreactivity with regards to lung squamous cell carcinoma.