A RETROSPECTIVE STUDY ON RECOGNIZABLE SYNDROMES ASSOCIATED WITH CRANIOFACIAL CLEFTS

Objective: There are about 300 to 600 syndromes associated with clefts in the craniofacial region. The cleft lip, cleft palate and cleft lip palate are the most common clefts seen in the craniofacial region. Sometimes these clefts are associated with other anomalies which are known as syndromic clefts. The objective of this study is to identify the syndromes associated with the clefts in the craniofacial region. Materials & methods: This retrospective study consists of  270 cases of clefts in the craniofacial region. The detailed case history including the maternal history, antenatal, natal, perinatal history and family history were taken from the patients and their parents.  Based on the clinical examination, radiological findings and genetic analysis  the different syndromes were identified. Results: 18 syndromic clefts were identified which belong to 10 different syndromes. It shows 6.67% of clefts are syndromic and remaining are nonsyndromic clefts. Conclusion: Median cleft face syndrome, Van der woude syndrome and Pierre Robin sequence are the common syndromes associated with the clefts in the craniofacial region.