优势比
基因型
人口
2型糖尿病
荟萃分析
2型糖尿病
等位基因
中国人口
中国
置信区间
作者
Qiong Chen,Hailan Yang,Yongliang Feng,Ping Zhang,Weiwei Wu,Shuzhen Li,Brian Thompson,Xin Wang,Tingting Peng,Fang Wang,Bingjie Xie,Pengge Guo,Mei Li,Ying Wang,Nan Zhao,Suping Wang,Yawei Zhang
标识
DOI:10.1177/1479164117745260
摘要
Gestational diabetes mellitus is a growing public health concern due to its large disease burden; however, the underlying pathophysiology remains unclear. Therefore, we examined the relationship between 107 single-nucleotide polymorphisms in insulin signalling pathway genes and gestational diabetes mellitus risk using a nested case-control study. The SOS1 rs7598922 GA and AA genotype were statistically significantly associated with reduced gestational diabetes mellitus risk ( ptrend = 0.0006) compared with GG genotype. At the gene level, SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for multiple comparisons. Moreover, AGGA and GGGG haplotypes in SOS1 gene were associated with reduced risk of gestational diabetes mellitus. Our study provides evidence for an association between the SOS1 gene and risk of gestational diabetes mellitus; however, its role in the pathogenesis of gestational diabetes mellitus will need to be verified by further studies.
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