Study on the Stability of Complexes of Gatifloxacin and other five Drugs by HPLC

Aim To study the stability of complexes of gatifloxacin and other five drugs at 25℃.Methods The samples of the complexes were collected in 24h after mixing gatifloxacin and other five drugs at 25℃,the content changes of gatifloxacin and the drugs were determined by means of HPLC.The insolute particles and pH of the samples were also determined by optical resinstance method and pH meter,respectively.Results The complexes (Ⅴ?Ⅵ?Ⅶ?Ⅷ) were no change of colour in 24h.The pH and particles of solutions,varied slightly in acceptable range of pharmacopoeia.The contents of gatifloxacin and three other tested drugs were more than 90% of their initial levels,while the contents of of the two tested drugs were lower than 90% of their initial levels.Conclusion Gatifloxacin and five other drugs were compatible,the contents of gatifloxacin was stable under the experiment condition.