May polydextrose potentially improve gut health in patients with chronic kidney disease?

Polydextrose (PDX) is a non-digestible oligosaccharide with a complex structure widely used in the food industry. Studies have shown many health benefits of polydextrose, including modulating the gut microbiota, improving the immune system, altering the lipid profile, and stimulating bowel function. Patients with chronic kidney disease (CKD) report gut dysbiosis, inflammation, dyslipidemia and constipation. These are major concerns that affect the quality of life. In this context, PDX can promote beneficial effects. However, little is known about PDX in CKD. This review discusses the possible beneficial effects of PDX on gut health for patients with CKD, particularly its impact on constipation.