光学测图
原位
离体
体内
波长
物理
生物医学工程
计算机科学
心脏病学
内科学
医学
光学
生物
生物技术
气象学
作者
Hanyu Zhang,Haley N. Patton,Garrett A. Wood,Ping Yan,Leslie M. Loew,Corey D. Acker,Gregory P. Walcott,Jack M. Rogers
标识
DOI:10.1109/embc40787.2023.10340445
摘要
Cardiac optical mapping has traditionally been performed in ex-vivo, motion-arrested hearts. Recently, in-situ cardiac optical mapping has been made possible by both motion correction techniques and long-wavelength voltage sensitive dyes (VSDs). However, VSDs have been observed to wash out quickly from blood-perfused in-situ hearts. In this study, we evaluate the performance of a newly developed VSD, di-5-ANEQ(F)PTEA, relative to an earlier VSD, di-4-ANEQ(F)PTEA. We find that di-5-ANEQ(F)PTEA persists over 3 times longer, produces improved signal-to-noise ratio, and does not prolong loading unacceptably.Clinical Relevance—Optical mapping has provided many insights into cardiac arrhythmias, but has traditionally been limited to ex-vivo preparations. The present findings extend the utility of optical mapping in the more realistic in-vivo setting and may eventually enable its use in patients.
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