盲肠
肠沙门氏菌
沙门氏菌
结肠炎
微生物学
殖民抵抗
沙门氏菌感染
生物
肠道细菌
殖民地化
炎症
免疫学
细菌
大肠杆菌
基因
生态学
生物化学
遗传学
作者
Katrin Ehrhardt,Guntram A. Grassl
出处
期刊:Methods in molecular biology
日期:2022-01-01
卷期号:: 201-213
被引量:3
标识
DOI:10.1007/978-1-0716-1971-1_17
摘要
Salmonella efficiently colonizes the cecum and proximal colon of mice where it induces inflammation resulting in colitis. To study intestinal infection of non-typhoidal Salmonella enterica serovars in mice, the colonization resistance of the intestine is overcome by transiently reducing the gut microbiota by an oral antibiotic treatment 1 day prior to infection with Salmonella. The in vivo colitis model is crucial for understanding the role of mucosal host defenses, analysis of histopathological changes, and the identification of host and bacterial factors leading to acute infections or facilitating bacterial persistence.
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