纳米囊
材料科学
模板
药物输送
聚合物
金属
金属有机骨架
纳米技术
化学工程
高分子化学
有机化学
纳米颗粒
冶金
复合材料
化学
吸附
工程类
作者
Lei Tang,Jiafu Shi,Xiaoli Wang,Shaohua Zhang,Hong Wu,Hongfan Sun,Zhongyi Jiang
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2017-06-09
卷期号:28 (27): 275601-275601
被引量:40
标识
DOI:10.1088/1361-6528/aa7379
摘要
A facile, efficient, and versatile approach is presented to synthesize pH-responsive nanocapsules (∼120 nm) by combining the advantages of metal-organic frameworks (MOFs) and metal-organic thin films. ZIF-8 nanoparticles are used as templates on which a thin film coating of iron(III)-catechol complexes is derived from the coordination between dopamine-modified alginate (AlgDA) and iron(III) ions. After the template removal, nanocapsules with a pH-responsive wall are obtained. Doxorubicin (Dox), a typical anticancer drug, is first immobilized in ZIF-8 frameworks through coprecipitation and then encapsulated in nanocapsules after the removal of ZIF-8. The structure of the iron(III)-catechol complex varies with pH value, thus conferring the Dox@Nanocapsules with tailored release behavior in vitro. Cytotoxicity tests illustrate the highly effective cytotoxicity of Dox@Nanocapsules towards cancer cells. This study provides a new method for preparing smart nanocapsules and offers more opportunities for the controlled delivery of drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI