Synthesis and Characterization of Bis(Dibenzylstannic Heteroaromatic Radical Carboxylate) Oxide

Eight new bis(dibenzylstannic heteroaromatic radical carboxylate)oxides (R - 2 - furanyl, 2 - furanvinyl, 2 - thiophenyl, 3 - pyridyl, 4 - pyridyl, 2 - pyridyl, 3 - indolymethyl, 3 - indolypropyl) were synthesized by the reaction of dibenzylstannic oxide with heteroarmotic radical substituted carboxylic acids in 1 : 1 molar ratio. The compounds were characterized by elemental analysis, MS,IR and NMR(1H, Sn). These results revealed that the compounds adopt the dicarboxylate tetraorganodistannoxane structure mode and the four carboxylate ligande were coordinated to Sn in bidentate. The 119Sn NMR spectroscopy indicated the presence of two distinct sixcoordinate tin centers. The compounds were tested in vitro against two human tumour cell lines, MCF - 7, a mammary tumour, and WiDr, a colon carcinoma. Some of them showed antitumor activities.