PIN1 inhibits ferroptosis in gastric cancer cells by regulating the CPEB1‑GPX4 pathway

experiments further suggest that PIN1 knockdown significantly reduces the tumorigenic potential of GC cells. A novel PIN1‑CPEB1‑GPX4 axis was identified, in which PIN1 downregulates CPEB1 to mediate ferroptosis resistance. This axis represents a potential therapeutic target, as PIN1 knockout demonstrates significant tumor suppression in animal models. The present study identifies a novel PIN1‑CPEB1‑GPX4 regulatory axis that controls ferroptosis, suggesting its potential as a therapeutic target for advanced GC.