医学
生物医学中的光声成像
病理
活检
放射科
铜
化学
作者
Melissa Y. Lucero,Tang Y,Zhang C,Su S,Joseph A. Forzano,Garcia,Huang X,Moreno D,Jefferson Y. Chan
标识
DOI:10.26434/chemrxiv.14397176.v1
摘要
The
development of high-performance photoacoustic (PA) probes that can monitor
disease biomarkers in deep-tissue has the potential to replace invasive medical
procedures such as a biopsy. However, such probes must be highly optimized for in
vivo performance and exhibit an exceptional safety profile. In this study,
we have developed PACu-1, the first PA probe designed for biopsy-free
assessment (BFA) of hepatic Cu via photoacoustic imaging. PACu-1 features a
Cu(I)-responsive trigger appended to an aza-BODIPY dye platform that has been
optimized for ratiometric sensing. Owing to its excellent performance, we were
able to detect basal levels of Cu in healthy wildtype mice, as well as elevated
Cu in a Wilson’s disease model and in a liver metastasis model. To showcase the
potential impact of PACu-1 for BFA, we conducted a blind study where we were
able to successfully identify a Wilson’s disease animal from a group of healthy
control mice with greater than 99.7% confidence.
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