自愈水凝胶
材料科学
极限抗拉强度
生物相容性
多孔性
壳聚糖
聚合物
化学工程
渗透
生物材料
复合数
PEG比率
复合材料
透明质酸
高分子化学
纳米技术
膜
化学
生物化学
财务
生物
经济
工程类
冶金
遗传学
作者
Siqi Tan,Yueshan Huang,Jun Lan,Xiao Han,Cen Ren-jing,Xiuhua Zhao,Yonghua Lao
标识
DOI:10.1080/10667857.2022.2059045
摘要
Mechanical properties of hyaluronic acid (HA) hydrogels are too poor to be prepared as an ultra-thin hydrogels, so to provide a supporting skeleton for them is important. Herein, the porous film based on chitosan(CS)、PEG-20000 and graphene oxide (GO) were prepared for ultra-thin hydrogels. CS is a suitable polymer to prepare films. The added PEG-20000 endowed the film porosity. And the addition of GO improved the mechanical of the film. When CS:PEG = 3:2 and the GO solution proportion was 15%, the porous film exhibited the best comprehensive properties, with a tensile strength of 5.593 MPa, an elongation at break of 45.833%, a water permeation of 1.4099 g at 12 h, a porosity of 62.3% and an average pore size of 1.88 um. Blood compatibility experiments and cell experiments have proved that the film hydrogel has strong biocompatibility, indicating it can be a promising biomaterial.
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