瞬时受体电位通道
内体
细胞生物学
TRPC公司
TRPV1型
溶酶体
生物
TRPV公司
神经科学
化学
细胞内
受体
生物化学
酶
作者
Christian Grimm,Maria Barthmes,Christian Wahl‐Schott
出处
期刊:Handbook of experimental pharmacology
日期:2014-01-01
卷期号:: 659-674
被引量:16
标识
DOI:10.1007/978-3-642-54215-2_26
摘要
TRPML3 belongs to the MCOLN (TRPML) subfamily of transient receptor potential (TRP) channels comprising three genes in mammals. Since the discovery of the pain sensing, capsaicin- and heat-activated vanilloid receptor (TRPV1), TRP channels have been found to be involved in regulating almost all kinds of our sensory modalities. Thus, TRP channel members are sensitive to heat or cold; they are involved in pain or osmosensation, vision, hearing, or taste sensation. Loss or mutation of TRPML1 can cause retina degeneration and eventually blindness in mice and men (mucolipidosis type IV). Gain-of-function mutations in TRPML3 cause deafness and circling behavior in mice. A special feature of TRPML channels is their intracellular expression. They mostly reside in membranes of organelles of the endolysosomal system such as early and late endosomes, recycling endosomes, lysosomes, or lysosome-related organelles. Although the physiological roles of TRPML channels within the endolysosomal system are far from being fully understood, it is speculated that they are involved in the regulation of endolysosomal pH, fusion/fission processes, trafficking, autophagy, and/or (hormone) secretion and exocytosis.
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