微尺度化学
分子马达
积分器
运动蛋白
纳米技术
动力蛋白
DNA
计算机科学
生物物理学
化学
材料科学
细胞生物学
生物
生物化学
带宽(计算)
数学教育
数学
计算机网络
微管
作者
Ryota Ibusuki,Tatsuya Morishita,Akane Furuta,S. Nakayama,Yoshio Matsumoto,Hiroaki Kojima,Kazuhiro Oiwa,Ken’ya Furuta
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-03-11
卷期号:375 (6585): 1159-1164
被引量:34
标识
DOI:10.1126/science.abj5170
摘要
Intracellular transport is the basis of microscale logistics within cells and is powered by biomolecular motors. Mimicking transport for in vitro applications has been widely studied; however, the inflexibility in track design and control has hindered practical applications. Here, we developed protein-based motors that move on DNA nanotubes by combining a biomolecular motor dynein and DNA binding proteins. The new motors and DNA-based nanoarchitectures enabled us to arrange the binding sites on the track, locally control the direction of movement, and achieve multiplexed cargo transport by different motors. The integration of these technologies realized microscale cargo sorters and integrators that automatically transport molecules as programmed in DNA sequences on a branched DNA nanotube. Our system should provide a versatile, controllable platform for future applications.
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