上皮-间质转换
HMGA2型
癌症
癌症研究
医学
回顾性队列研究
内科学
科克伦图书馆
转移
生物
肿瘤科
基因
荟萃分析
小RNA
遗传学
作者
Carmen Vallina,Rosa María López‐Pintor,José González‐Serrano,Juan Carlos de Vicente,Gonzalo Hernández,Corina Lorz
出处
期刊:Oral Oncology
[Elsevier]
日期:2021-06-01
卷期号:117: 105310-105310
被引量:15
标识
DOI:10.1016/j.oraloncology.2021.105310
摘要
Epithelial-mesenchymal transition (EMT) is considered the initial step in the invasion-metastasis cascade. The aim of this systematic review was to study the signature of genes involved in the EMT process in oral cancer (OC) confirmed by protein expression and its possible relationship with oral squamous cell carcinoma (OSCC) prognostic variables.A search of the scientific literature was carried out with no start date restriction until 17 September 2020 in the electronic databases Pubmed/MEDLINE, Web of Science, Cochrane Library and Scopus, following specific eligibility criteria. The methodological quality of the included studies was assessed using the Newcastle-Ottawa tool.A total of 8 retrospective cohort studies were included, all of them performed in China and with low risk of bias. Overexpression of the genes HNRNPC, ITGA5, HMGA2 and SRSF3, and low expression of ALDH3A1 and ARID2 promote EMT in OC. The more advanced clinical stages of the TNM classification were significantly associated with overexpression of HNRNPC, ITGA5, HMGA2 and SRSF3, and low expression of ARID2.HNRNPC, ITGA5, HMGA2, SRSF3, ALDH3A1 and ARID2 genes were associated with EMT process. Over- or under-expression of these genes is associated with worse stages of OSCC and/or worse prognosis of the tumor. Further studies on this topic are needed in different countries to be able to confirm these results, since the detection of these genes can help to know which tumors have a worse prognosis.
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