生物医学中的光声成像
对偶(语法数字)
急性肾损伤
医学
材料科学
肾损伤
肾
生物医学工程
泌尿科
放射科
内科学
艺术
物理
光学
文学类
作者
Penghui Cheng,Kanyi Pu
出处
期刊:Methods in Enzymology
日期:2021-01-01
卷期号:: 271-300
被引量:1
标识
DOI:10.1016/bs.mie.2021.06.020
摘要
In this chapter, we introduced a diagnostic approach for acute kidney injury (AKI) via photoacoustic imaging. We provided detailed synthetic procedures of a biomarker-activatable photoacoustic agent (FPRR) with high renal clearance efficiency. We also provided protocols for in vitro characterization, live-cell imaging, and in vivo imaging in a drug-induced AKI mice model. Compared to near-infrared fluorescence imaging, photoacoustic imaging is more sensitive with higher signal-to-background ratio. As such, our approach serves as a general guideline in the development of photoacoustic agents for diagnosis of urological diseases. With this tool in hand, researchers in the field of optical imaging may be inspired to develop other photoacoustic agents for early stage disease diagnosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI