生物
免疫球蛋白超家族
分子生物学
富含亮氨酸重复
互补DNA
分子克隆
基因
cDNA文库
抗体
遗传学
作者
Akemi Nagasawa,Ryo Kubota,Yutaka Imamura,Kentaro Nagamine,Yimin Wang,Shuichi Asakawa,Jun Kudoh,Shinsei Minoshima,Yukihiko Mashima,Yoshihisa Oguchi,Nobuyoshi Shimizu
出处
期刊:Genomics
[Elsevier]
日期:1997-09-01
卷期号:44 (3): 273-279
被引量:36
标识
DOI:10.1006/geno.1997.4889
摘要
We isolated cDNAs for a novel protein with a calculated molecular mass of 46 kDa, containing a leucine-rich repeat (LRR) with conserved flanking sequences and a C2-type immunoglobulin (Ig)-like domain. This novel protein was considered to be a new member of the Ig superfamily and was named ISLR (immunoglobulin superfamily containing LRR). These domains are known to be important for protein–protein interaction or cell adhesion, and therefore it is possible that the novel protein ISLR may also interact with other proteins or cells. Northern blot analysis showed the presence of a 2.4-kb transcript in various human tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach, and spinal cord as well as fetal lung and fetal kidney. The ISLR gene was mapped on human chromosome 15q23–q24 by fluorescencein situhybridization.
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