医学
结直肠癌
内科学
胃肠病学
疾病
岩藻糖苷酶
肿瘤科
癌症
生物
分子生物学
糖蛋白
岩藻糖
作者
Julia Fernández-Rodrı́guez,Daniel Ayude,de la Cadena,Martínez-Zorzano Vs,de Carlos A,A Caride-Castro,de Castro G,Rodríguez-Berrocal Fj
出处
期刊:PubMed
日期:2000-01-01
卷期号:24 (2): 143-9
被引量:6
摘要
The aim of this study was to examine the prognostic value of the alpha-L-fucosidase enzyme to determine whether it can help in the early recognition of colorectal cancer cases at high risk of tumor recurrence. One hundred and twenty-three colorectal carcinoma patients treated by curative surgery were studied. The alpha-L-fucosidase activity was assayed in the tumor and in normal mucosa from each patient using a fluorometric method. Seven other clinical and pathologic features were also studied. To evaluate the impact of each variable over the disease-free interval, a postoperative 30-month follow-up of patients was performed, and a statistical survival analysis was carried out. The recurrence appearance was higher when the relative decrease of alpha-L-fucosidase activity was more than 52% (log-rank test, P = .0261). The results of this work indicate that alpha-L-fucosidase activity appears to be a good independent prognostic factor of tumoral recurrence in colorectal carcinoma.
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