病毒学
谱系(遗传)
效价
抗体
中和抗体
生物
病毒载量
抗体效价
拉伤
病毒
免疫学
基因
遗传学
解剖
作者
Cheng Wei,Ailing Dai,Jialin Fan,Yan Li,Anni Chen,Xia Zhou,Luo Man-lin,Xiaoyan Yang,Jian‐Kui Liu
标识
DOI:10.1038/s41598-019-47239-9
摘要
Abstract The objective of the present study was to determine the cross-protection of Ingelvac PRRS MLV against challenge with the new lineage 1 PRRSV emerged in China in pigs. Two lineage 1 PRRSV strains (FJZ03 and FJWQ16 originated from recombination event between NADC30 and JXA1-like strain). We found that pigs vaccinated with the vaccine were protected against challenge with the FJZ03 as shown by fewer days of clinical fever, reduced lung pathology scores, lower PRRS virus load in the blood and developed broadly neutralizing antibodies with high titers to FJZ03. In contrast, vaccine provided limited protection against challenge with FJWQ16 with higher fever, lower antibody titers, lower neutralizing antibodies and higher viral loads in blood. These results demonstrate PRRSV-MLV provides incomplete protection against new lineage 1 PRRSVs.
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