Lipoxygenase Inhibitory Lignans from Salvia santolinifolia

Santolinol, a new lignan has been isolated from the chloroform soluble fraction ofSalvia santolinifolia and assigned the structure 1 on the basis of spectral studies including 2D NMR. In addition three bifuranolignans namely didemethylpinoresinol 2, (+) fraxi-resinol 3 and (+) 1 -hydroxysyringaresinol 4 have also been isolated for the first time from this species. All these compounds showed potent inhibitory potential against the enzyme lipoxygenase.