Organocatalytic enantioselective cross-aldol reaction of aryl ketones with heteroaromatic trifluoromethyl ketone hydrates for the synthesis of α-trifluoromethyl tertiary alcohols

A tertiary amine thiourea-catalyzed asymmetric cross-aldol reaction of aryl ketones with trifluoromethyl ketone hydrates via enolate intermediates has been developed.