Yeast-Derived Beta-Glucan Supplementation on Antibody Response Following Influenza Vaccination: A Protocol for a Randomized, Placebo-Controlled Study (M-Unity)

Objectives: Yeast beta-glucans have shown immune-modulating effects by enhancing innate and adaptive immune responses through cytokine release and antibody production, among other immunomodulating effects. This study aims to determine the effect of yeast-derived beta-glucan supplementation on antibody titer response to influenza vaccination. Secondary outcomes include cytokine profile, incidence of fever, cold and flu symptoms, and self-perceived fatigue.