生物正交化学
合成生物学
纳米技术
自愈水凝胶
计算机科学
组织工程
再生医学
生化工程
干细胞
化学
工程类
点击化学
计算生物学
材料科学
生物
生物医学工程
细胞生物学
有机化学
组合化学
作者
Ryan Gharios,Richard C. Francis,Cole A. DeForest
出处
期刊:Matter
[Elsevier]
日期:2023-12-01
卷期号:6 (12): 4195-4244
被引量:3
标识
DOI:10.1016/j.matt.2023.10.012
摘要
Summary
There is a growing interest in the development of technologies to probe and direct in vitro cellular function for fundamental organoid and stem cell biology, functional tissue and metabolic engineering, and biotherapeutic formulation. Recapitulating many critical aspects of the native cellular niche, hydrogel biomaterials have proved to be a defining platform technology in this space, catapulting biological investigation from traditional two-dimensional (2D) culture into the 3D world. Seeking to better emulate the dynamic heterogeneity characteristic of all living tissues, global efforts over the last several years have centered on upgrading hydrogel design from relatively simple and static architectures into stimuli-responsive and spatiotemporally evolvable niches. Toward this end, advances from traditionally disparate fields, including bioorthogonal click chemistry, chemoenzymatic synthesis, and DNA nanotechnology, have been co-opted and integrated to construct 4D-tunable systems that undergo preprogrammed functional changes in response to user-defined inputs. In this review, we highlight how advances in synthetic, semisynthetic, and bio-based chemistries have played a critical role in the triggered creation and customization of next-generation hydrogel biomaterials. We also chart how these advances stand to energize the translational pipeline of hydrogels from bench to market and close with an outlook on outstanding opportunities and challenges that lay ahead.
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