Flow Chemistry of Metal Carbenoid Species towards Selective Organic Synthesis

This review deals with C1 carbenoid chemistry, with a focus on lithium carbenoid species generated in flash flow systems. Strict control of the temperature, residence time, and mixing efficiency has led to various transformation reactions involving epoxidation, cyclopropanation, and homologation, among others. The use of other metal species, including trifluoromethyl potassium (CF3K) and magnesium/zinc carbenoids, in flow systems is also introduced. 1. Introduction 2. Flow Reactions Involving Carbenoid Species 3. Conclusion