Angeliticin B, a new chromone isolated from Angelica polymorpha Maxim

A new chromone, angeliticin B (1) together with nine known compounds, psoralene (2), isoimperatorin (3), (S)-(-)-2′-methoxypeucedanin hydrate (4), (S)-(-)-oxypeucedanin (5), xanthotoxin (6), isopimpinellin (7), 1′-O-β-D-glucopyranosyl-(2′S, 3′R)-3′-hydroxymarmesin (8), sec-O-glucosylhamaudol (9) and vanillin (10) were isolated from the methanol extract of Angelica polymorpha Maxim. The structures of these compounds were elucidated through a comprehensive analysis of standard spectral data (MS, IR, and NMR). Compound 1 exhibited antioxidant activity with IC₅₀ = 198.57 μM in DPPH experiment and 31.71 μM in ABTS experiment. Compound 2, 6, 7 exhibited ABTS radical scavenging activity with IC₅₀ ranging from 105.96 μM to 167.67 μM. Compound 3 demonstrated a synergistic induction effect on nigericin-activated NLRP3 inflammasome in THP-1 cell by LDH release method.