The low molecular weight hyaluronic acid(LMWHA) and hyaluronic acid oligosaccharides(o-HA) have the activities of antioxidation,immunomodulation,wound healing,angiogenesis and antitumor.Hyaluronic acid(HA) can be degraded by oxidants to LMWHA and o-HA.This paper introduces the oxidation degradation of HA.