Objective To observe the relations of renal function in type 2 diabetes patients and related factors to explore the risk factors of renal dysfunction. Methods A total of 492 cases were recruited from the department of endocrinology in our study. Their clinical data were collected and biochemical indicators were measured.The data were analyzed by SPSS13.0 software. Results Age,course,systolic blood pressure,total cholesterol,low-density lipoprotein,blood urea nitrogen,serum creatinine,serum uric acid and urinary albumin excretion in type 2 diabetes with renal dysfunction group were significantly higher than the normal renal function group (P0.05).They were relevant with age,course and urinary albumin excretion (P0.05). Conclusion Age and course is the main influencing factors of renal dysfunction in type 2 diabetes patients.