溶解
材料科学
耐折性
溶剂
铸造
剂型
生物利用度
化学工程
复合材料
色谱法
化学
聚合物
有机化学
医学
药理学
工程类
乙基纤维素
作者
Rajat Pawar,Ravi Sharma,Pravin Kumar Sharma,G. N. Darwhekar
出处
期刊:Journal of Drug Delivery and Therapeutics
[Society of Pharmaceutical Tecnocrats]
日期:2019-11-15
被引量:2
标识
DOI:10.22270/jddt.v9i6.3676
摘要
Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved .Mouth dissolving film has potential to improve onset of action lower the dosing and eliminate the fear of chocking. Formulation of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the most preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. This review gives an idea about formulation techniques, evaluation parameters, overview on packaging and some available marketed products of mouth dissolving films.
Keywords: Mouth dissolving film, solvent casting, fast disintegration
科研通智能强力驱动
Strongly Powered by AbleSci AI