去肽
部分
化学
聚酮
基因组
立体化学
计算生物学
作者
Yuto Homma,Akihiro Sugawara,Yohei Morishita,Kento Tsukada,Taro Ozaki,Teigo Asai
标识
DOI:10.1021/acs.orglett.2c01172
摘要
Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A heterologous reconstitution of the identified biosynthetic pathway predictably afforded a new cyclic depsipeptide composed of l-leucine, l-tryptophan, and a polyketide moiety. Interestingly, the 10-membered macrocycle structure generated equilibrium to an unprecedented cyclol structure. This study demonstrates the advantage of a synthetic biology method in achieving rational access to new natural products.
科研通智能强力驱动
Strongly Powered by AbleSci AI