脚手架
生化工程
农药
过程(计算)
知识产权
广谱
GSM演进的增强数据速率
SPARK(编程语言)
计算机科学
纳米技术
业务
电信
材料科学
化学
农业
工程类
生物
组合化学
生态学
操作系统
程序设计语言
数据库
标识
DOI:10.1021/acs.jafc.1c07910
摘要
Over the years, scaffold hopping has proven to be a powerful tool in the agrochemical optimization process. It offers the opportunity to modify known molecular lead structures to improve a range of parameters, including biological efficacy and spectrum, physicochemical properties, toxicity, stability, and to secure new intellectual property. Very often the disclosure of a new chemical structure can spark a multitude of competitor activities, where scaffold hopping plays a crucial role in the optimization process as well as for the generation of new intellectual property. Herein, recent examples of scaffold hopping in early phase herbicide research based on competitor inspired activities will be discussed using examples of how these research campaigns can often result in the registration of new crop protection products.
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