Effect of Resveratrol on Human Scar Fibroblasts and Scar-derived Fibroblasts of Rabbit Ears

Objective To study the effects of resveratrol on viability of fibroblasts and scar-derived fibroblasts of rabbit ears.(Methods ①Various) concentrations of resveratrol were added into the medium and co-incubated with FB for difierent time period.FCM assay was employed to detect proliferation of fibroblast.②To find animal model,various concentrations of resveratrol were tested for hypertrophic scar of rabbit ears.Results ①the data of the present study demonstrated that resveratrol in various concentrations inhibite proliferation of fibroblast.②resveratrol in concentrations of 150、300、400 μmol/L inhibited index of hypertrophic scar.Compared with controls,the index of hypertrophic scar were decreased by 78.8%、61.2%、47.0%.(Conclusions Resveratrol) may inhibit viability of fibroblasts and there is a dose-time-effect trend.