Protective effect of ulinastatin on liver reperfusion injury in patients undergoing hepatectomy

To investigate the Protective effects of ulinastatin on liver function in patients undergoing Hepatectomy. Twenty-eight primary patients with hepatic carcinoma scheduled for hepatectomy were divided into two groups of 14 each: controlled group(group C) and ulinastatin group (group W). In group W, patient received ulinastatin 10 000 u/kg. Plasma levers of alanine transaminase(ALT), aspartate transaminase(AST) and total bilirubin (TBIL) were measured before operation (T1), 10 min after hepatic inflow occlusion (T2), 20 min after recovering hepatic inflow (T3), 1h after recovering hepatic inflow (T4), 24 h (T5), 3 days (T6) and 5 days (T7) after operation. In the T2, T3, T4, T5, T6 and T7, the plasma levers of ALT, AST, TBIL were lower in group W than that in C group. The plasma levers of ALT, AST in the T3, T4 and T5 in group W were remarkably lower than those in group C (P 0.05). On the first postoperative day, The plasma levers of TBIL in group W were remarkably lower than those in group C (P 0.05). [Conclusions] It suggest that ulinastatin can effectly protect liver function in patients undergoing hepatectomy.