Salvia miltiorrhiza extract ameliorated ovarian damage induced by cyclophosphamide in mice by multidimensional mechanisms

Our findings verified that SM could significantly reduce primordial follicle (PMF) loss and follicular atresia, and ameliorate CTX-induced ovarian dysfunction and poor fertility, but didn't affect the anti-tumor effect of CTX and tumor growth. Further compelling evidence was provided that, the protective effect of SM may be related to apoptosis inhibition, low oxidative stress, vascular protection and anti-fibrotic effect, which further confirmed the comprehensive protection of SM on CTX-induced ovarian damage, thereby supporting its potential clinical efficacy in mitigating chemotherapy-induced decline of ovarian function.