Unlocking Spatiotemporal Dynamics: Precise Dual-Modal Bioimaging of Endogenous c-MYC mRNA in Tumors via a CHA-Activated Ratiometric Nanoplatform

, and the afterglow signal of ZGMD was observed within 6 min in mice after preirradiation, which unlocked spatiotemporal dynamics of dual-modal bioimaging. Importantly, the ZGMD nanoplatform could visualize the dynamic fluctuations of endogenous c-MYC within tumors by dual-modal spatiotemporal bioimaging, providing a noninvasive tool for real-time assessment in disease diagnosis and cancer therapy.