Schistosoma japonicum peptide SJMHE1 promotes peripheral nerve regeneration via macrophage migrasome-derived miR-26b-5p targeting the PTEN/AKT axis

Our findings reveal a novel mechanism by which SJMHE1 promotes peripheral nerve regeneration through macrophage-Schwann cell communication mediated by miRNA delivery via macrophage migrasomes. This study highlights SJMHE1 as a promising therapeutic peptide for PNI and indicates that targeting migrasome-mediated communication between macrophages and Schwann cells may represent a new therapeutic strategy for PNI.