医学
Peutz-Jeghers综合征
背景(考古学)
肠套叠(内科疾病)
胃肠道癌
胃肠道
重症监护医学
普通外科
癌症
结直肠癌
内科学
生物
古生物学
作者
Andrew Latchford,Susan Clark
标识
DOI:10.1016/j.bpg.2022.101789
摘要
There are two main problems in the clinical management of the gastrointestinal (GI) tract in patients with Peutz-Jeghers syndrome (PJS), namely long-term cancer risk and managing polyp related complications (of which the most important clinically is intussusception). Given the rarity of this condition, the evidence base upon which to make recommendations is small. Furthermore, controversies persist regarding the relationship between PJ polyps, cancer development and cancer risk. In this article we will explore some of these controversies, to put into context the recommendations for clinical management of these patients. We will provide an overview, particularly focusing on clinical data, and on the recommendations for clinical management and surveillance of the GI tract in PJS. We highlight knowledge gaps which need to be addressed by further research.
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