Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

A highly regio- and stereoselective trans-iodofluorination of N-(1-alkynyl)amides with NIS and Et₃N·3HF was achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to excellent yields.