18F‐Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts

Abstract A new method for the 18 F‐radiolabeling of aromatic compounds based on the aromatic nucleophilic substitution (S N Ar) reaction using triarylsulfonium salts has been developed. Experiments and DFT calculations indicated that sulfonium ions have the potential to be optimized for labeling nonactivated and deactivated aryl rings that have Hammett σ P substituent constants greater than –0.170. This method is applicable to a range of halogen‐substituted aryl systems including nonactivated and deactivated aryl rings. In particular, the high radiochemical yield of [ 18 F]‐4‐fluoroiodobenzene from precursor 1a represents a ready source of compound 1b for subsequent use in palladium‐catalyzed C–H activation/C–C bond‐forming reactions.