抗惊厥药
拉莫三嗪
化学
芳基
苯妥英钠
质子核磁共振
体内
立体化学
药理学
癫痫
有机化学
医学
烷基
生物
精神科
生物技术
作者
Bingi Pujari Mallikarjuna,G.V. Suresh Kumar,B. S. Sastry,Nagaraj,K. P. Manohara
出处
期刊:Journal of Zhejiang University-science B
[Springer Nature]
日期:2007-06-01
卷期号:8 (7): 526-532
被引量:16
标识
DOI:10.1631/jzus.2007.b0526
摘要
In the present research, a series of 5,6-bis aryl 1,2,4-triazines 5a∼5f were synthesized by condensation of various benzils 4a∼4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 5a, 5b and 5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopic data.
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