Wnt信号通路
Notch信号通路
细胞生物学
干细胞
生物
祖细胞
信号转导
串扰
Hes3信号轴
自分泌信号
上皮
肠上皮
细胞命运测定
细胞培养
转录因子
遗传学
物理
光学
基因
作者
Toshio Nakamura,Kiichiro Tsuchiya,Mamoru Watanabe
标识
DOI:10.1007/s00535-007-2087-z
摘要
Continuous renewal of the intestinal epithelium requires coordinated regulation to maintain the balance between proliferation and differentiation of the epithelial stem cells and immature progenitor cells. Canonical Wnt signaling has long been regarded as the signaling pathway playing a central role in this epithelial cell fate determination; however, recent studies have shown that Notch signaling is also indispensable for this process. Here, we review the current concepts of how the Wnt and Notch pathways control intestinal epithelial cell fate decisions, particularly focusing on their crosstalk at both tissue and cellular levels. As several features are shared between stem cell renewal and cancer cell renewal, comprehensive understanding of how the Wnt and Notch signaling pathways cooperate and integrate in the gut epithelium has significant implications for the development of novel therapeutic modalities for intestinal neoplasia.
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