Drug Metabolizing Enzymes

Dioxygen activation by cytochromes P450 - a role for multiple oxidants in the oxidation of substrates, Alfin D.N. Vaz application of LC/MS, LC/NMR, NMR and stable isotopes in identifying and characterizing metabolites, A.E. Mutlib and John P. Shockcor bioactivation, Jack Uetrecht chemically reactive metabolites in drug discovery and development, Thomas A. Baillie cytochrome P450 and its place in drug discovery and development, Dennis Smith cytochrome P450 in laboratory animal species, Margit Spatzenegger, Stephanie L. Born and James R. Halpert typical and atypical enzyme, Kinetics J. Brian Houston, Kathryn E. Kenworthy and Aleksandra Galetin cytochrome P450 reaction phenotyping, Larry C. Wienkers and Jeffrey C. Stevens drug-drug interactions and the cytochromes P450, Kenneth A. Bachmann, Barbara J. Ring and Steven A. Wrighton CYP gene induction by xenobiotics and drugs, Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Martine Daujat, Lionel Drocourt, Lydiane Pichard-Garcia, Marie-Jose Vilarem, Patrick Maurel, Sylvie Klieber, Francois Torreilles, Martine Bourrie, Francois Guillou and Gerard Fabre cytochrome P450 pharmacogenetics, Robert L. Haining and Aiming Yu role of intestinal cytochromes P450 in drug deposition, Mary F. Paine and Kenneth E. Thummel prediction of hepatic clearance in humans from experimental animals and in vitro data, Masato Chiba, Yoshihiro Shibata, Hiroyuki Takahashi, Yasuyuki Ishii and Yuichi Sugiyama non-P450 mediated oxidative metabolism of xenobiotics, Dieter Lang and Amit S. Kalgutkar the role of sulfotransferases (SULTs) and UDP-glucuronosyltransferases (UGTs) in human drug clearance and bioactivation, Michael W.H. Coughtrie and Michael B. Fisher.