材料科学
结晶度
细菌纤维素
半纤维素
纤维素
极限抗拉强度
生物相容性材料
木质素
聚合物
生物医学工程
复合材料
化学工程
医学
化学
有机化学
工程类
作者
Selestina Gorgieva,Janja Trček
出处
期刊:Nanomaterials
[MDPI AG]
日期:2019-09-20
卷期号:9 (10): 1352-1352
被引量:263
摘要
Bacterial cellulose (BC) is ultrafine, nanofibrillar material with an exclusive combination of properties such as high crystallinity (84%-89%) and polymerization degree, high surface area (high aspect ratio of fibers with diameter 20-100 nm), high flexibility and tensile strength (Young modulus of 15-18 GPa), high water-holding capacity (over 100 times of its own weight), etc. Due to high purity, i.e., absence of lignin and hemicellulose, BC is considered as a non-cytotoxic, non-genotoxic and highly biocompatible material, attracting interest in diverse areas with hallmarks in medicine. The presented review summarizes the microbial aspects of BC production (bacterial strains, carbon sources and media) and versatile in situ and ex situ methods applied in BC modification, especially towards bionic design for applications in regenerative medicine, from wound healing and artificial skin, blood vessels, coverings in nerve surgery, dura mater prosthesis, arterial stent coating, cartilage and bone repair implants, etc. The paper concludes with challenges and perspectives in light of further translation in highly valuable medical products.
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