发病机制
多发性硬化
微生物群
免疫系统
免疫学
双歧杆菌
肠道微生物群
医学
母乳喂养
肠道菌群
生物
生物信息学
遗传学
细菌
儿科
乳酸菌
作者
Mehdi Toghi,Sara Bitarafan,Hosein Delavar Kasmaei,Soudeh Ghafouri‐Fard
标识
DOI:10.1016/j.msard.2019.101378
摘要
Multiple sclerosis (MS) is an autoimmune disorder in which the immunopathogenesis is not fully understood. In the recent years, the role of gut microbiome in the pathogenesis of this disorder has been highlighted. Bifidobacteria as a component of gut microbiome might also be involved in MS pathogenesis. Being emerged in early days after birth, bifidobacteria have a prominent role in immune system maturation and function. Some factors like mode of delivery, breast feeding, mother's blood group and her secretory state and also environmental factors could influence its level in the early infancy, which may remain throughout lifetime. In this review, we discussed possible immunopathogenic link between the bifidobacteria and MS.
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