Hydrogel systems for targeted cancer therapy

光热治疗 癌症治疗 癌症治疗 癌症 药物输送 放射治疗 药品 热疗 生物相容性 靶向给药 医学 纳米技术 药理学 材料科学 外科 内科学 冶金
作者
Xinlin Li,Xinyi Xu,Mengfei Xu,Zhaoli Geng,Ping Ji,Yi Liu
出处
期刊:Frontiers in Bioengineering and Biotechnology [Frontiers Media]
卷期号:11 被引量:83
标识
DOI:10.3389/fbioe.2023.1140436
摘要

When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer.
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