慢性疼痛
免疫系统
类阿片
神经科学
上瘾
伤害
医学
转化式学习
心理学
生物信息学
免疫学
生物
受体
内科学
教育学
作者
Sanam Mustafa,Juliana Esma Bajic,Benjamin Barry,Susan Evans,Kariel R. Siemens,Mark R. Hutchinson,Peter M. Grace
标识
DOI:10.1016/j.neuropharm.2023.109459
摘要
The transition from acute to chronic pain is an ongoing major problem for individuals, society and healthcare systems around the world. It is clear chronic pain is a complex multidimensional biological challenge plagued with difficulties in pain management, specifically opioid use. In recent years the role of the immune system in chronic pain and opioid pharmacology has come to the forefront. As a highly dynamic and versatile network of cells, tissues and organs, the immune system is perfectly positioned at the microscale level to alter nociception and drive structural adaptations that underpin chronic pain and opioid use. In this review, we highlight the need to understand the dynamic and adaptable characteristics of the immune system and their role in the transition, maintenance and resolution of chronic pain. The complex multidimensional interplay of the immune system with multiple physiological systems may provide new transformative insight for novel targets for clinical management and treatment of chronic pain. This article is part of the Special Issue on “Opioid-induced changes in addiction and pain circuits”.
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