The role of FHL1 in tumors

• The regulation of FHL1 expression in tumor is governed by both epigenetic modifications, transcriptional and post-transcriptional mechanisms. • FHL1 acts as a tumor suppressor gene and an oncogene. • The LIM domains in FHL1 mediate protein–protein interactions, allowing FHL1 to interact with a variety of binding partners and participate in diverse tumors. • Introduced the importance of FHL1 in tumor diagnosis and treatment. • The roles of other FHL1 isoforms in cancer.