Modulating ATOH1 and POU4F3 Pathways to Enhance Hair Cell Regeneration and Inhibit Ferroptosis in Cochlear Support Cells

levels, improving cell survival. In a cisplatin-induced hearing loss mouse model, modulating the ATOH1/POU4F3 axis significantly improved ABR and DPOAE thresholds and restored hair cell structure and arrangement, confirmed by SEM and immunostaining. Together, these findings provide new mechanistic insights into how transcriptional regulation links regeneration and cell death resistance, highlighting a promising therapeutic target for hearing restoration.