Copper-Catalyzed Synthesis of Quinazolin-4(1H)-one from Amine-Trichloroacetonitrile Adduct and Isatoic anhydride

A rapid and direct route for the new synthesis of various quinazolines-4 (1H)-ones with appropriate yields through a three-component reaction consisting of the amine-trichloroacetonitrile adduct and isatoic anhydride is a remarkable achievement in organic chemistry. The use of CuO as the catalyst in DMF under reflux conditions at 110 °C for 4 hours offers reaction conditions, which are conducive to the formation of the desired products while maintaining good selectivity. The simplicity of the one-pot synthesis and using the available raw materials contribute to the ease of purification of the synthesized quinazolines-4 (1H)-ones, streamlining the overall synthetic process. The synthesized product is often found in drugs and other bioactive molecules.