Enhanced Interfacial Electric Field of an S‐Scheme Heterojunction by an Ultrasonication‐Triggered Piezoelectric Effect for Sonocatalytic Therapy of Bacterial Infections

Sonodynamic therapy indicates advantages in combating antibiotics-resistant bacteria and deep tissue infections, but challenges remain in the less efficient charge transfer and reactive oxygen species (ROS) generation of sonosensitizers. Herein, an effective bactericidal strategy is developed through enhancing the interfacial electric field (IEF) of S-scheme heterojunctions by an ultrasonication-triggered piezoelectric effect. Hollow barium titanate (hBT) nanoparticles (NPs) were prepared through template etching, followed by in situ assembly of tetrakis (4-carboxyphenyl)porphyrin (TCPP) with Zn²⁺ to obtain hBT@ZnTCPP. Both experimental and theoretical evidences support the notion that an IEF is generared from ZnTCPP to hBT. Compared to metalloporphyrins with Fe³⁺, Mn³⁺, Cu²⁺ and Ni²⁺, the stronger reduction of ZnTCPP induced by elevation of the orbital energy level of porphyrins after Zn²⁺ coordination leads to formation of S-scheme heterojunctions. The ultrasonication-activated polarization field enhances IEF and boosts energy band bending of hBT@ZnTCPP to promote electron-hole separations and ROS generations. Planktonic methicillin-resistant Staphylococcus aureus and their derived biofilms are completely destroyed within 5 min under ultrasonication through up-regulating genes of glucose catabolism and ion transportation and down-regulating genes of ribosomal synthesis and transmembrane transporter. Thus, this study demonstrates molecular-level modulation of energy levels for S-scheme heterojunction formation to achieve efficient sonocatalytic therapy of bacterial infections.