A Low-Noise Chopper Amplifier Designed for Multi-Channel Neural Signal Acquisition

This paper proposed the design of a low-noise, low total harmonic distortion (THD) chopper amplifier for neural signal acquisition. A dc servo loop (DSL) based on active Gm-C integrator is proposed to reject the electrode-dc-offset (EDO). Architecture of a complementary input very low-transconductance (VLT) operational transconductance amplifier (OTA) was proposed and integrated in the active Gm-C integrator to improve the linearity as well as to reduce the noise, featuring a transconductance ranging from 45 pS to a few nS. The proposed amplifier was fabricated in a TSMC 0.18-μm CMOS process, occupying an area of 0.2 mm ² , featuring a power consumption of 3.24 μW/channel under a 1.8-V supply voltage. The THD for a 5-mV _pp input is lower than -61 dB. An input-referred thermal noise power spectral density (PSD) of 39 nV/√Hz is measured. The measured input-referred noise is 0.65 μV _rms in the 0.3-200-Hz frequency band and 2.14 μV _rms in the 200-Hz- 5-kHz frequency band, respectively, leading to a noise-efficiency factor of 2.37 (0.3-200 Hz) and 1.56 (0.2 k-5 kHz). In addition, the high-pass corner frequency can be precisely configured and linearly adjusted with the external bias current from 0.35 to 54.5 Hz.